Pricing updated 2019-07-17. Prices are subject to change without notice.
7-Methylguanine is a metabolite of the natural purine base whose N9 position is available for chemical modifications.1 This genotoxic adduct can be generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods.2 It is also considered to be a carcinogenic biomarker for cigarette smoking that is detectable in urine.3
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Kozma, A., Ibáñez, S., Silaghi-
Lee, S., Bowman, B.R., Ueno, Y., et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-
Lee, H.L., Hsueh, Y.M., Chung, C.J., et al. Correlation between the urine profile of 4-