An endogenous κ1b-opioid receptor agonist
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Dynorphin B (trifluoroacetate salt)

Item No. 18178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dynorphin B (swine), trifluoroacetate salt
Synonyms
  • Dynorphin B-13
  • Rimorphin
Molecular Formula
C74H115N21O17 • XCF3COOH
Formula Weight
1570.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
278 nm
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)CCSC)=O)=O)CC1=CC=C(O)C=C1)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C20H30N4O8S.C2HF3O2/c1-33-7-6-14(20(31)32)22-19(30)16(10-26)24-18(29)15(23-17(28)13(21)9-25)8-11-2-4-12(27)5-3-11;3-2(4,5)1(6)7/h2-5,13-16,25-27H,6-10,21H2,1H3,(H,22,30)(H,23,28)(H,24,29)(H,31,32);(H,6,7)/t13-,14-,15-,16-;/m0./s1
InChi Key
OASQDVZWJHZUJM-ORGRJDPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $95

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    1 mg

    $168

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    5 mg

    $647

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    10 mg

    $922

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    Product Description

    Dynorphin B is a 13-residue opioid peptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system.1,2 It acts as a κ1b-opioid receptor agonist (Ki = 1.1 nM) and has been implicated in antinociceptive functions.3 Dynorphin B has also been used to prime cardiogenesis in pluripotent embryonic stem cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berman, Y., Juliano, L., and Devi, L.A. Specificity of the dynorphin-processing endoprotease: Comparison with prohormone convertases. J. Neurochem. 72(5), 2120-2196 (1999).

    2. Janecka, A., Fichna, J., and Janecki, T. Opioid receptors and their ligands. Curr. Top. Med. Chem. 4(1), 1-17 (2004).

    3. Dhawan, B.N., Cesselin, F., Raghubir, R., et al. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 48(4), 567-592 (1996).

    4. Ventura, C., Zinellu, E., Maninchedda, E., et al. Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells. Circ. Res. 92, 623-629 (2003).