A non-selective NSAID
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Metabolite(s)
22161Tolmetin β-D-Glucuronide
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Tolmetin (sodium salt hydrate)

Item No. 18195

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid, monosodium, dihydrate
CAS Number
64490-92-2
Molecular Formula
C15H14NO3 • Na [2H2O]
Formula Weight
315.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
255, 320 nm
SMILES
CC1=CC=C(C(C2=CC=C(CC([O-])=O)N2C)=O)C=C1.[Na+].O.O
InChi Code
InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1
InChi Key
QQILXENAYPUNEA-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

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    10 g

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    25 g

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    Product Description

    Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.1 It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warner, T.D., Giuliano, F., Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA 96(13), 7563-7568 (1999).

    2. Zheng, X., Zhang, L., Zhai, J., et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 586(1), 55-59 (2012).

    3. Flanagan, J.U., Yosaatmadja, Y., Teague, R.M., et al. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS One 7(8), 1-16 (2012).