A stable PGI2 analog
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13,14-dehydro-15-cyclohexyl Carbaprostacyclin

Item No. 18212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3aS-(2E,3aα,4α,5β,6aα)]-5-[hexahydro-5-hydroxy-4-[(1-hydroxycyclohexyl)ethynyl]-2(1H)-pentalenylidene]-pentanoic acid
CAS Number
145375-81-1
Molecular Formula
C21H30O4
Formula Weight
346.5
Purity
≥98%
Formulation
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >10 mg/mlDMSO: >5 mg/mlEthanol: >20 mg/mlPBS (pH 7.2): >80 mg/ml
SMILES
OC1(C#C[C@H]2[C@H](O)C[C@H]3[C@@H]2C/C(C3)=C/CCCC(O)=O)CCCCC1
InChi Code
InChI=1S/C21H30O4/c22-19-14-16-12-15(6-2-3-7-20(23)24)13-18(16)17(19)8-11-21(25)9-4-1-5-10-21/h6,16-19,22,25H,1-5,7,9-10,12-14H2,(H,23,24)/b15-6+/t16-,17+,18-,19+/m0/s1
InChi Key
LGIPMFCHTFFLFR-PRYZLTTQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 µg

    $69

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    100 µg

    $127

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    500 µg

    $525

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    Product Description

    13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is comparable to the potency of carbaprostacyclin.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanger, T., Lopp, M., Müraus, A., et al. Synthesis of a novel, optically active 15-nonstereogenic carbaprostacyclin. Synthesis 10, 925-927 (1992).

    2. Kobzar, G., Shelkovnikov, S., Mardla, V., et al. A 15-nonstereogenic carbocyclic analogue of prostacyclin: Effects on human platelets and uterine artery. J. Lipid Mediat. Cell Signal. 10(3), 2443-2449 (1994).