A metabolite of estradiol 3-sulfate
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Estradiol 3-sulfate 17β-Glucuronide (potassium salt)

Item No. 18224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-3-(sulfooxy)estra-1,3,5(10)-trien-17-yl,β-D-glucopyranosiduronic acid, dipotassium salt
CAS Number
10392-35-5
Molecular Formula
C24H30O11S • 2K
Formula Weight
604.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H][C@]12[C@@]([C@@](CC[C@@H]3O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C([O-])=O)O4)([H])[C@]3(C)CC2)([H])CCC5=CC(OS([O-])(=O)=O)=CC=C51.[K+].[K+]
InChi Code
InChI=1S/C24H32O11S.2K/c1-24-9-8-14-13-5-3-12(35-36(30,31)32)10-11(13)2-4-15(14)16(24)6-7-17(24)33-23-20(27)18(25)19(26)21(34-23)22(28)29;;/h3,5,10,14-21,23,25-27H,2,4,6-9H2,1H3,(H,28,29)(H,30,31,32);;/q;2*+1/p-2/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+;;/m1../s1
InChi Key
NUSNDWFRAHTWCY-LXMSUNLNSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

    $135

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    5 mg

    $593

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    Product Description

    Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most commonly leading to excretion in urine and bile.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raftogianis, R., Creveling, C., Weinshilboum, R., et al. Chapter 6: Estrogen metabolism by conjugation. J. Natl. Cancer Inst. Monogr. 27, 113-124 (2000).

    2. Loe, D.W., Almquist, K.C., Cole, S.P., et al. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. The Journal of Biological Chemisty 271(16), 9683-9689 (1996).