A derivative of cortisol
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Hydrocortisone 21-hemisuccinate (sodium salt)

Item No. 18226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(3-carboxy-1-oxopropoxy)-11β,17-dihydroxy-pregn-4-ene-3,20-dione, monosodium salt
CAS Number
125-04-2
Synonyms
  • Cortisol 21-hemisuccinate
  • Hydrocortisone sodium succinate
  • ST51037292
  • U-4905
Molecular Formula
C25H33O8 • Na
Formula Weight
484.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
242 nm
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3(O)C(COC(CCC([O-])=O)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O.[Na+]
InChi Code
InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
InChi Key
HHZQLQREDATOBM-CODXZCKSSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 mg

    $39

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    500 mg

    $145

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    1 g

    $251

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    Product Description

    Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 µM for IL-6).1 It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, B.S., Chung, E.Y., Yun, Y.P., et al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol. Pharm. Bull. 24(6), 701-703 (2001).

    2. Whitehead, R.H., and Robinson, P.S. Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice. Am. J. Physiol. Gastrointest. Liver Physiol. 296(3), G455-G460 (2009).