An NQO1 inhibitor
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Diminutol

Item No. 18237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
CAS Number
361431-33-6
Synonyms
  • NG72
Molecular Formula
C19H26N6OS
Formula Weight
386.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
226, 249, 324 nm
SMILES
CC(C)N1C2=NC(N[C@@H](CO)C(C)C)=NC(SC3=CC=CC(N)=C3)=C2N=C1
InChi Code
InChI=1S/C19H26N6OS/c1-11(2)15(9-26)22-19-23-17-16(21-10-25(17)12(3)4)18(24-19)27-14-7-5-6-13(20)8-14/h5-8,10-12,15,26H,9,20H2,1-4H3,(H,22,23,24)/t15-/m0/s1
InChi Key
NLQYQPZBKDUXKS-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $54

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    1 mg

    $102

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    5 mg

    $418

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    10 mg

    $732

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    Product Description

    Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis.1 At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wignall, S.M., Gray, N.S., Chang, Y.T., et al. Identification of a novel protein regulating microtubule stability through a chemical approach. Chem. Biol. 11, 135-146 (2004).