An 11β-HSD inhibitor
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Carbenoxolone (sodium salt)

Item No. 18240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,20β)-3-(3-carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid, disodium salt
CAS Number
7421-40-1
Molecular Formula
C34H48O7 • 2Na
Formula Weight
614.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
250 nm
SMILES
[O-]C([C@@]1(C)CC[C@]([C@@]2([H])C1)(C)CC[C@@](C2=C3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](OC(CCC([O-])=O)=O)CC[C@]5(C)[C@@]4([H])C3=O)=O.[Na+].[Na+]
InChi Code
InChI=1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33
InChi Key
BQENDLAVTKRQMS-SBBGFIFASA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $42

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    5 g

    $174

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    10 g

    $307

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    25 g

    $662

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    Product Description

    Carbenoxolone is a derivative of β-glycyrrhetinic acid (Item No. 11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to β-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties.1 Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Item No. 10007815) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension.2 It is also reported to inhibit 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sircus, W. Carbenoxolone sodium. Gut 13(10), 816-824 (1972).

    2. Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J. Clin. Endocrinol. Metab. 88(6), 2384-2392 (2003).

    3. Hellmich, H.L., Rojo, D.R., Micci, M.A., et al. Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury. PLoS One 8(1), e53230 (2013).