An internal standard for the quantification of fluoxetine
Related Products
Unlabeled Version(s)
14418Fluoxetine (hydrochloride)
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Fluoxetine-d5 (hydrochloride)

Item No. 18253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-3-(phenyl-d5)-3-(4-(trifluoromethyl)phenoxy)propan-1-amine, monohydrochloride
CAS Number
1173020-43-3
Molecular Formula
C17H13D5F3NO • HCl
Formula Weight
350.8
Purity
≥99% deuterated forms (d1-d5)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 12.5 mg/mlEthanol: 12.5 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
227, 263 nm
SMILES
CNCCC(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])OC2=CC=C(C(F)(F)F)C=C2.Cl
InChi Code
InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/i2D,3D,4D,5D,6D;
InChi Key
GIYXAJPCNFJEHY-CERKJNTMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $90

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    1 mg

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    5 mg

    $696

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    Product Description

    Fluoxetine-d5 is intended for use as an internal standard for the quantification of fluoxetine (Item No. 14418) by GC- or LC-MS. Fluoxetine is a selective serotonin reuptake inhibitor, displaying a marked preference for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM).1 Formulations containing fluoxetine have been effective in the treatment of major depression as well as other psychiatric disorders.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tatsumi, M., Groshan, K., Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340(2-3), 249-258 (1997).

    2. Farley, R.L. Pharmacological treatment of major depressive disorder in adolescents. ScientificWorldJournal 5, 420-426 (2005).

    3. Pacher, P., and Kecskemeti, V. Trends in the development of new antidepressants. Is there a light at the end of the tunnel? Curr. Med. Chem. 11(7), 925-943 (2004).