A selective PDE4 inhibitor
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Ro 20-1724

Item No. 18272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone
CAS Number
29925-17-5
Synonyms
  • 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Molecular Formula
C15H22N2O3
Formula Weight
278.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
230, 280 nm
SMILES
COC1=C(OCCCC)C=C(CC2CNC(N2)=O)C=C1
InChi Code
InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChi Key
PDMUULPVBYQBBK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $36

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    50 mg

    $55

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    100 mg

    $96

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    Product Description

    Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 µM).1,2 It weakly inhibits PDE3 with a Ki value greater than 25 µM.1 Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species.3 It is often used to study cAMP-related functions in vascular cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reeves, M.L., Leigh, B.K., and England, P.J. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem. J. 241, 535-541 (1987).

    2. Soderling, S.H., Bayuga, S.J., and Beavo, J.A. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc. Natl. Acad. Sci. USA 95, 8991-8996 (1998).

    3. Totani, L., Piccoli, A., Dell'Elba, G., et al. Phosphodiesterases type-4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury. Arterioscler. Thromb. Vasc. Biol. 34(8), 1689-1696 (2014).

    4. Zhai, K., Hubert, F., Nicolas, V., et al. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7(10), 1-13 (2012).