A ligand for nucleobindin 1
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MJN228

Item No. 18275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-methyl-1-piperazinyl)(5-nitro-3-phenyl-1H-indol-2-yl)-methanone
CAS Number
459168-97-9
Molecular Formula
C20H20N4O3
Formula Weight
364.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 25 mg/mL
λmax
278 nm
SMILES
O=C(N1CCN(C)CC1)C2=C(C3=CC=CC=C3)C4=CC([N+]([O-])=O)=CC=C4N2
InChi Code
InChI=1S/C20H20N4O3/c1-22-9-11-23(12-10-22)20(25)19-18(14-5-3-2-4-6-14)16-13-15(24(26)27)7-8-17(16)21-19/h2-8,13,21H,9-12H2,1H3
InChi Key
BLSWPPPBUQFKHH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $357

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    10 mg

    $593

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    25 mg

    $1,183

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    Product Description

    MJN228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1), blocking binding of the probe arachidonoyl ethanolamide-diazirine with an IC50 value of 3.3 µM.1 It prevents probe binding to NUCB1 in Neuro2a cells at concentrations as low as 10 µM. MJN228 has been used to elucidate the role of NUCB1 in lipid metabolic pathways in cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niphakis, M.J., Lum, K.M., Cognetta, A.B., III, et al. A global map of the lipid-binding proteins and their ligandability in cells. Cell 161, 1668-1680 (2015).