A selective, reversible ALDH2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Small Molecule Modulators
Small Molecule Inhibitors

Research Area

CVT-10216

Item No. 18318

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]-benzoic acid
CAS Number
1005334-57-5
Synonyms
  • GS-455534
Molecular Formula
C24H19NO7S
Formula Weight
465.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
234, 259 nm
SMILES
OC(C1=CC=CC(COC2=CC=C(C(C(C3=CC=C(NS(C)(=O)=O)C=C3)=CO4)=O)C4=C2)=C1)=O
InChi Code
InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
InChi Key
YYOOFJZTRCPVFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $130

    Add

    10 mg

    $238

    Add

    25 mg

    $535

    Add
    Product Description

    Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the major oxidative pathway of alcohol metabolism. CVT-10216 is a reversible inhibitor of ALDH2 (IC50 = 29 nM) that demonstrates >40-fold selectivity for ALDH2 over the cytosolic isoform, ALDH1.1 CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.1 This compound has also been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety.1 The efficacy of CVT-10216 has also been examined in rodent models of drug addiction or binge eating of high-fat or high-sugar diets.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Overstreet, D.H., Knappa, D.J., Breese, G.R., et al. A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol. Biochem. Behav. 94(2), 255-261 (2009).

    2. Bocarsly, M.E., Hoebel, B.G., Paredes, D., et al. GS 455534 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats. Behav.Pharmacol. 25(2), 147-157 (2014).