A DNA ligase inhibitor
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L189

Item No. 18374

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
CAS Number
64232-83-3
Molecular Formula
C11H10N4OS
Formula Weight
246.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 0.3 mg/ml
λmax
222, 294, 360, 378 nm
SMILES
NC(N1)=C(/N=C/C2=CC=CC=C2)C(NC1=S)=O
InChi Code
InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+
InChi Key
SAKOXVNKDMWWLF-AWNIVKPZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $178

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    25 mg

    $417

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    50 mg

    $601

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    Cayman Chemical
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    Product Description

    L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).1 It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.1 L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Zhong, S., Zhu, X., et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68(9), 3169-3177 (2008).