A selective inhibitor of cardiac late sodium current
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GS967

Item No. 18376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
CAS Number
1262618-39-2
Molecular Formula
C14H7F6N3O
Formula Weight
347.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/mlEthanol: 12 mg/ml
λmax
247 nm
SMILES
FC(OC1=CC=C(C(C=C2)=CN3C2=NN=C3C(F)(F)F)C=C1)(F)F
InChi Code
InChI=1S/C14H7F6N3O/c15-13(16,17)12-22-21-11-6-3-9(7-23(11)12)8-1-4-10(5-2-8)24-14(18,19)20/h1-7H
InChi Key
FEVBKJITJDHASC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $103

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    50 mg

    $161

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    100 mg

    $262

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    Product Description

    GS967 is a selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts.1 It can inhibit A. sulcata toxin II–induced late INa in ventricular myocytes and isolated hearts with IC50 values of 0.13 and 0.21 µM, respectively.1 GS967 causes minimal inhibition of the delayed-rectifier potassium current nor does it affect L- or T-type calcium channel currents, sodium-calcium exchanger currents, or a panel of 162 receptors, ion channels, transporters, and enzymes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Belardinelli, L., Liu, G., Smith-Maxwell, C., et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. J. Pharmacol. Exp. Ther. 344(1), 23-32 (2013).