An immunosuppressive drug that inhibits DHODH
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Vidofludimus

Item No. 18377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid
CAS Number
717824-30-1
Synonyms
  • 4SC-101
Molecular Formula
C20H18FNO4
Formula Weight
355.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 25 mg/ml
λmax
261, 293 nm
SMILES
COC1=CC(C2=CC(F)=C(NC(C3=C(C(O)=O)CCC3)=O)C=C2)=CC=C1
InChi Code
InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)
InChi Key
XPRDUGXOWVXZLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $534

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    Product Description

    Vidofludimus is an immunosuppressive drug that inhibits DHODH (IC50s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms, respectively).1,2 Through this action, it inhibits the proliferation of T cells and B cells and the secretion of IL-17 (IC50s = 12.9, 3.7, and 6.0 µM, respectively, in human cells).1,2 Oral administration of vidofludimus improves both chronic dextran sodium sulfate-induced and acute TNBS-induced colitis in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fitzpatrick, L.R., Deml, L., Hoffmann, C., et al. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm. Bowel Dis. 16(10), 1763-1777 (2010).

    2. Fitzpatrick, L.R. Novel pharmacological approaches for inflammatory bowel disease: Targeting key intracellular pathways and the IL-23/IL-17 axis. Int. J. Inflam. 389404 (2016).