An inhibitor of HIF-PH2
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FG-2216

Item No. 18382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine
CAS Number
223387-75-5
Synonyms
  • IOX3
  • YM-311
Molecular Formula
C12H9ClN2O4
Formula Weight
280.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.5 mg/ml
λmax
221, 257, 327, 341 nm
SMILES
OC1=C(C(NCC(O)=O)=O)N=C(Cl)C2=CC=CC=C21
InChi Code
InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
InChi Key
OUQVKRKGTAUJQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    10 mg

    $283

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    25 mg

    $587

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    Product Description

    FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar).1 It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, Y.R., Kim, H.T., Lee, S.L., et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg. Med. Chem. 23(21), 5953-5957 (2013).

    2. Hsieh, M.M., Linde, N.S., Wynter, A., et al. HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaque. Blood 110(6), 2140-2147 (2007).