An antiparasitic agent
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Fexinidazole

Item No. 18393

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole
CAS Number
59729-37-2
Synonyms
  • HOE239
Molecular Formula
C12H13N3O3S
Formula Weight
279.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 10 mg/mlEthanol: 0.2 mg/ml
λmax
227, 257, 299 nm
SMILES
CSC1=CC=C(OCC2=NC=C([N+]([O-])=O)N2C)C=C1
InChi Code
InChI=1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3
InChi Key
MIWWSGDADVMLTG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Fexinidazole is an antiparasitic agent.1 It is active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC50s = 0.95-3.31 µM). Fexinidazole inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC50s = 5.6 and 2.8 µM, respectively).2 Fexinidazole (50 to 30 mg/kg per day) reduces parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi.3 Formulations containing fexinidazole have been used in the treatment of African sleeping sickness and Chagas disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Su, L., Pan, P., Yan, P., et al. Role of vimentin in modulating immune cell apoptosis and infammatory responses in sepsis. Sci. Rep. 9(1), 5747 (2019).

    2. Wyllie, S.G., Patterson, S., Stojanovski, L., et al. The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis. Sci. Transl. Med. 4(119), 119re111 (2012).

    3. Bahia, M.T., de Andrade, I.M., Martins, T.A.F., et al. Fexinidazole: A potential new drug candidate for Chagas disease. PLoS Negl. Trop. Dis. 6(11), e1870 (2012).