An inhibitor of microtubule polymerization
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CYT997

Item No. 18395

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]-urea
CAS Number
917111-44-5
Synonyms
  • Lexibulin
Molecular Formula
C24H30N6O2
Formula Weight
434.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:20): 0.04 mg/mlDMSO: 20 mg/mlEthanol: 16 mg/ml
λmax
210, 237, 265, 317 nm
SMILES
CC1=C(N[C@@H](CCC)C2=CC=CN=C2)N=C(C3=CC(OC)=C(NC(NCC)=O)C=C3)N=C1
InChi Code
InChI=1S/C24H30N6O2/c1-5-8-19(18-9-7-12-25-15-18)28-22-16(3)14-27-23(30-22)17-10-11-20(21(13-17)32-4)29-24(31)26-6-2/h7,9-15,19H,5-6,8H2,1-4H3,(H2,26,29,31)(H,27,28,30)/t19-/m0/s1
InChi Key
MTJHLONVHHPNSI-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    50 mg

    $482

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    Cayman Chemical
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    Product Description

    CYT997 is an inhibitor of microtubule polymerization (IC50 = ~3 µM).1 It induces cell cycle arrest at the G2/M phase and is cytotoxic against a panel of cancer cell lines (IC50s = 0.009-0.101 µM). CYT997 increases human umbilical vein endothelial cell (HUVEC) monolayer permeability (IC50 = ~0.08 µM), a marker of vascular collapse. It decreases liver metastasis in a murine DMH-induced colon cancer model when administered at doses of 5, 10, and 15 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burns, C.J., Fantino, E., Philips, I.D., et al. CYT997: A novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Mol. Cancer Ther. 8(11), 3036-3045 (2009).

    2. Burns, C.J., Fantino, E., Powell, A.K., et al. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo. J. Pharmacol. Exp. Ther. 339(3), 799-806 (2011).