An inhibitor of NEP
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LHW090-A7

Item No. 18410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-3'-chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino]-[1,1'-biphenyl]-4-propanoic acid, monosodium salt
Molecular Formula
C20H21ClNO4 • Na
Formula Weight
397.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
257 nm
SMILES
ClC1=CC=CC(C2=CC=C(C[C@H](N[C@H](C(OCC)=O)C)C([O-])=O)C=C2)=C1.[Na+]
InChi Code
InChI=1S/C20H22ClNO4.Na/c1-3-26-20(25)13(2)22-18(19(23)24)11-14-7-9-15(10-8-14)16-5-4-6-17(21)12-16;/h4-10,12-13,18,22H,3,11H2,1-2H3,(H,23,24);/q;+1/p-1/t13-,18-;/m0./s1
InChi Key
AGNFMTOJUUTYHZ-ZYJMRSDMSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    LHW090-A7 is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins.1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwaki, Y., Kawanami, T., Ksander, G.M., et al. Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors. (2011).