An HIV-1 attachment inhibitor
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Pro-drug Form(s)
37708BMS 663068
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BMS 626529

Item No. 18413

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-ethanedione
CAS Number
701213-36-7
Molecular Formula
C24H23N7O4
Formula Weight
473.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.1 mg/mlDMSO: 0.3 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.03 mg/mlEthanol: 0.2 mg/ml
λmax
233, 315 nm
SMILES
O=C(N1CCN(C(C(C2=CNC3=C(N4C=NC(C)=N4)N=CC(OC)=C32)=O)=O)CC1)C5=CC=CC=C5
InChi Code
InChI=1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3
InChi Key
QRPZBKAMSFHVRW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    BMS 626529 is an inhibitor of HIV-1 attachment.1,2 It binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry.1 BMS 626529 reduces infectivity of laboratory strains and clinical isolates of HIV-1 (EC50s = 0.4-2,000 and 25-2,000 nM, respectively) with cytotoxic concentration (CC50) values greater than 100 μM in a panel of mammalian cell lines.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Langley, D.R., Kimura, S.R., Sivaprakasam, P., et al. Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action. Proteins 83(2), 331-350 (2015).

    2. Nowicka-Sans, B., Gong, Y.-F., McAuliffe, B., et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob. Agents Chemother. 56(7), 3498-3507 (2012).