A natural bacterial product and GPR132 agonist
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Commendamide

Item No. 18421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-hydroxy-1-oxohexadecyl)-glycine
CAS Number
193825-78-4
Synonyms
  • N-acyl-3-hydroxypalmitoyl-Glycine
Molecular Formula
C18H35NO4
Formula Weight
329.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/ml
SMILES
O=C(O)CNC(CC(O)CCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C18H35NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(20)14-17(21)19-15-18(22)23/h16,20H,2-15H2,1H3,(H,19,21)(H,22,23)
InChi Key
MZUHHHSFDVDBCZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $45

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    1 mg

    $86

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    5 mg

    $360

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    10 mg

    $630

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    Product Description

    Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs).1 Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cohen, L.J., Kang, H.S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc. Natl. Acad. Sci. USA 112(35), E4825-E4834 (2015).