A partial agonist of 5-HT1A, 5-HT1B, and 5-HT2B receptors
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Eltoprazine (hydrochloride)

Item No. 18428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine, monohydrochloride
CAS Number
98206-09-8
Synonyms
  • DU-28,853
  • DU-28,893
Molecular Formula
C12H16N2O2 • HCl
Formula Weight
256.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
216 nm
SMILES
N1(C2=CC=CC3=C2OCCO3)CCNCC1.Cl
InChi Code
InChI=1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H
InChi Key
JFSOSUNPIXJCIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $197

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    25 mg

    $387

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    Product Description

    Eltoprazine is a phenylpiperazine compound that acts as a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively).1 It exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schipper, J., Tulp, M.T., and Sijbesma, H. Neurochemical profile of eltoprazine. Drug Metabol. Drug Interact. 8(1-2), 85-114 (1990).

    2. de Boer, S.F., Lesourd, M., Mocaer, E., et al. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J. Pharmacol. Exp. Ther. 288(3), 1125-1133 (1999).