A partial agonist of 5-HT1A, 5-HT1B, and 5-HT2B receptors
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Eltoprazine (hydrochloride)

Item No. 18428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine, monohydrochloride
CAS Number
98206-09-8
Synonyms
  • DU-28,853
  • DU-28,893
Molecular Formula
C12H16N2O2 • HCl
Formula Weight
256.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
216 nm
SMILES
N1(C2=CC=CC3=C2OCCO3)CCNCC1.Cl
InChi Code
InChI=1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H
InChi Key
JFSOSUNPIXJCIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $106

    Add

    10 mg

    $197

    Add

    25 mg

    $387

    Add
    Product Description

    Eltoprazine is a phenylpiperazine compound that acts as a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively).1 It exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schipper, J., Tulp, M.T., and Sijbesma, H. Neurochemical profile of eltoprazine. Drug Metabol. Drug Interact. 8(1-2), 85-114 (1990).

    2. de Boer, S.F., Lesourd, M., Mocaer, E., et al. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J. Pharmacol. Exp. Ther. 288(3), 1125-1133 (1999).