A reversible inhibitor of GBF1
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Golgicide A

Item No. 18430

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline
CAS Number
1005036-73-6
Synonyms
  • GCA
Molecular Formula
C17H14F2N2
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
241, 294 nm
SMILES
FC1=CC2=C(C(F)=C1)NC(C3=CN=CC=C3)C4C2C=CC4
InChi Code
InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2
InChi Key
NJZHEQOUHLZCOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $132

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    25 mg

    $306

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    Product Description

    Golgicide A is a reversible inhibitor of the brefeldin A (Item No. 11861)-resistant, cis-Golgi ArfGEF, GBF1 (IC50 = 3.3 µM).1 Inhibition of GBF1 via golgicide A can result in rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network.1 Golgicide A does not affect the association of the adaptor protein, AP-1, or the Arf1-binding protein, GCA3, with the trans-Golgi network nor does it interfere with the activity of the ArfGEFs, BIG1 or 2.1 Golgicide A can arrest the secretion of soluble and membrane-associated proteins at the ER-Golgi intermediate compartment, as well as prevent endocytic transport of Shiga toxin to the trans-Golgi network.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saenz, J.B., Sun, W.J., Chang, J.W., et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat. Chem. Biol. 5(3), 157-165 (2009).