A natural retinoid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Natural Products

Research Area

Neuroscience
Ophthalmology

all-trans Retinal

Item No. 18449

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
retinal
CAS Number
116-31-4
Synonyms
  • Retinaldehyde
  • Vitamin A aldehyde
Molecular Formula
C20H28O
Formula Weight
284.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 16 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
380 nm
SMILES
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C([H])=O)C(C)(C)CCC1
InChi Code
InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChi Key
NCYCYZXNIZJOKI-OVSJKPMPSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $50

    Add

    250 mg

    $99

    Add

    500 mg

    $149

    Add

    1 g

    $224

    Add
    Product Description

    all-trans Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.1 all-trans Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.2 As a chemically reactive aldehyde, all-trans retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noy, N. Retinoid-binding proteins: Mediators of retinoid action. Biochem. J. 348(Pt. 3), 481-495 (2000).

    2. Kiser, P.D., Golczak, M., Maeda, A., et al. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim. Biophys. Acta 1821(1), 137-151 (2012).