A reversible inhibitor of exocytosis
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Exo1

Item No. 18455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-fluorobenzoyl)amino]-benzoic acid, methyl ester
CAS Number
75541-83-2
Synonyms
  • Exocytic Inhibitor 1
  • NSC 214045
Molecular Formula
C15H12FNO3
Formula Weight
273.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mM
λmax
235, 267, 314 nm
SMILES
O=C(OC)C1=CC=CC=C1NC(C2=CC=C(F)C=C2)=O
InChi Code
InChI=1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChi Key
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $81

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    50 mg

    $357

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    Product Description

    Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 µM).1 It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, Y., Yu, S., Lasell, T.K.R., et al. Exo1: A new chemical inhibitor of the exocytic pathway. Proc. Natl. Acad. Sci. USA 100(11), 6469-6474 (2003).