An anxiolytic that suppresses seizures
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Valnoctamide

Item No. 18456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-ethyl-3-methyl-pentanamide
CAS Number
4171-13-5
Synonyms
  • NSC 32363
  • NSC 34092
  • Valmethamide
  • Valoctamidum
Molecular Formula
C8H17NO
Formula Weight
143.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CCC(C(N)=O)C(C)CC
InChi Code
InChI=1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)
InChi Key
QRCJOCOSPZMDJY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $61

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    25 mg

    $103

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    100 mg

    $268

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    Product Description

    Valnoctamide is an isomer of the valproic acid amide, valpromide. It has been marketed as an anxiolytic and sedative compound and suppresses neuropathic pain.1,2 Unlike valpromide, valnoctamide is not metabolized to its acid form, valnoctic acid, in vivo and has no teratogenicity.1 It abolishes the activity of myo-inositol-1-phosphate synthase in human brain crude homogenates (Ki = 0.18 mM).3 Valnoctamide suppresses electrographic seizures in animal models of status epilepticus, suggesting potential applications in managing epilepsy.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rogawski, M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69(3), 273-294 (2006).

    2. Winkler, I., Blotnik, S., Shimshoni, J., et al. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. Br. J. Pharmacol. 146, 198-208 (2005).

    3. Shaltiel, G., Mark, S., Kofman, O., et al. Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing. Pharmacol. Rep. 59(4), 402-407 (2007).

    4. Spampanato, J., and Dudek, F.E. Valnoctamide enhances phasic inhibition: A potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia 55(9), e94-e98 (2014).