A TSPO agonist
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FGIN-1-27

Item No. 18461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-fluorophenyl)-N,N-dihexyl-1H-indole-3-acetamide
CAS Number
142720-24-9
Molecular Formula
C28H37FN2O
Formula Weight
436.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
224, 301 nm
SMILES
FC(C=C1)=CC=C1C2=C(CC(N(CCCCCC)CCCCCC)=O)C(C=CC=C3)=C3N2
InChi Code
InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
InChi Key
VUWXAQFLTSBUDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $119

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    50 mg

    $215

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    Product Description

    FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone (Item No. 16930).1 Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Curr. Med. Chem. 13(17), 1991-2001 (2006).