A metabolite of taurolithocholic acid
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Taurolithocholic Acid 3-sulfate (sodium salt)

Item No. 18468

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β)-24-oxo-3-(sulfooxy)cholan-24-yl]amino]-ethanesulfonic acid, disodium salt
CAS Number
64936-83-0
Synonyms
  • 3-Sulfotaurolithocholic acid
  • 3S-TLCA
  • TLCA3S
  • TLC-S
Molecular Formula
C26H43NO8S2 • 2Na
Formula Weight
607.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMSO: 20 mg/mLEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/mL
SMILES
O=C(NCCS([O-])(=O)=O)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS([O-])(=O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+].[Na+]
InChi Code
InChI=1S/C26H45NO8S2.2Na/c1-17(4-9-24(28)27-14-15-36(29,30)31)21-7-8-22-20-6-5-18-16-19(35-37(32,33)34)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23H,4-16H2,1-3H3,(H,27,28)(H,29,30,31)(H,32,33,34);;/q;2*+1/p-2/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m
InChi Key
YHTVOGLKSGJIDL-RLHFEMFKSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid (Item No. 17275).1 TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).

    2. Blazquez, A.G., Briz, O., Romero, M.R., et al. Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol. Pharmacol. 81(2), 273-283 (2012).

    3. Muili, K.A., Wang, D., Orabi, A.I., et al. Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. The Journal of Biological Chemisty 288(1), 570-580 (2013).