An HCV RdRp polymerase inhibitor
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ABT-333

Item No. 18482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-methanesulfonamide
CAS Number
1132935-63-7
Synonyms
  • Dasabuvir
Molecular Formula
C26H27N3O5S
Formula Weight
493.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 20 mg/mlDMSO: 20 mg/ml
λmax
244 nm
SMILES
CC(C)(C)C1=C(OC)C(C2=CC3=CC=C(NS(C)(=O)=O)C=C3C=C2)=CC(N4C=CC(NC4=O)=O)=C1
InChi Code
InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
InChi Key
NBRBXGKOEOGLOI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    ABT-333 is an inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp; IC50s = 0.0022-0.0107 µM for genotypes 1a and 1b).1 It is selective for HCV genotype 1 polymerases over genotypes 2, 3, and 4 (IC50s = 0.9->20 µM), as well as human polymerases (IC50s = >100 µM). Formulations containning ABT-333, ombitasvir, paritaprevir, and ritonavir have been used in the treatment of HCV genotype 1 infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kati, W., Koev, G., Irvin, M., et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob. Agents Chemother. 59(3), 1505-1511 (2015).