An inhibitor of platelet activation
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12(S)-HETrE

Item No. 18483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12S-hydroxy-8Z,10E,14Z-eicosatrienoic acid
CAS Number
72710-10-2
Molecular Formula
C20H34O3
Formula Weight
322.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 2 mg/mlDMF: MisebleDMSO: MisebleEthanol: MisciblePBS (pH 7.2): 0.8 mg/ml
λmax
235 nm
SMILES
CCCCC/C=C\C[C@H](O)/C=C/C=C\CCCCCCC(O)=O
InChi Code
InChI=1S/C20H34O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h8,10-11,13-14,17,19,21H,2-7,9,12,15-16,18H2,1H3,(H,22,23)/b11-8-,13-10-,17-14+/t19-/m0/s1
InChi Key
YYIXZLMPKIFFGQ-ONNNWOQGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $102

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    50 µg

    $193

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    100 µg

    $365

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    Product Description

    12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).1 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 µM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ikei, K.N., Yeung, J., Apopa, P.L., et al. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation. J. Lipid Res. 53(12), 2546-2559 (2012).

    Product Citations

    Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS. Clin. Chem. Lab. Med. 59(11), 1811-1823 (2021).