A natural sesquiterpene
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Dehydrocostus lactone

Item No. 18485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one
CAS Number
477-43-0
Synonyms
  • (-)-Dehydrocostus lactone
Molecular Formula
C15H18O2
Formula Weight
230.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
C=C([C@H](CC1)[C@H](O2)[C@]3([H])[C@](CCC3=C)([H])C1=C)C2=O
InChi Code
InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChi Key
NETSQGRTUNRXEO-XUXIUFHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $60

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    10 mg

    $86

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    Product Description

    Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine.1 Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells.2,3,4 It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pandey, M.M., Rastogi, S., and Rawat, A.K. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant. J. Ethnopharmacol. 110(3), 379-390 (2007).

    2. Wang, C.Y., Tsai, A.C., Peng, C.Y., et al. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One 7(2), (2012).

    3. Lohberger, B., Rinner, B., Stuendl, N., et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One 8(6), e66300 (2013).

    4. Li, X., Peng, Z., and Su, C. Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone. Int. J. Mol. Sci. 16(5), 10888-10906 (2015).

    5. Butturini, E., Cavalieri, E., Carcereri de Prati, A., et al. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation. PLoS One 6(5), e20174 (2011).

    6. Scarponi, C., Butturini, E., Sestito, R., et al. Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolide. PLoS One 9(9), (2014).