A selective sodium/bicarbonate cotransporter blocker
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S0859

Item No. 18497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide
CAS Number
1019331-10-2
Molecular Formula
C29H24ClN3O3S
Formula Weight
530.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(C=C1)=CC=C1CN(C(C2=CC=CC=C2Cl)=O)CC(C=C3)=CC=C3C(C=CC=C4)=C4S(NC#N)(=O)=O
InChi Code
InChI=1S/C29H24ClN3O3S/c1-21-10-12-22(13-11-21)18-33(29(34)26-7-2-4-8-27(26)30)19-23-14-16-24(17-15-23)25-6-3-5-9-28(25)37(35,36)32-20-31/h2-17,32H,18-19H2,1H3
InChi Key
ITDBPOSLOROLMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes.1 It inhibits intracellular pH recovery in myocytes with a Ki value of 1.7 µM, with full inhibition occurring at ~30 µM.1 S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig.2 S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ch'en, F.F.T., Villafuerte, F.C., Swietach, P., et al. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart. Br. J. Pharmacol. 153(5), 972-982 (2008).

    2. Yamamoto, T., Swietach, P., Rossini, A., et al. Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig. J. Physiol. 562(Pt 2), 455-475 (2005).

    3. Kumar, S., Flacke, J.P., Kostin, S., et al. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovasc. Res. 89(2), 392-400 (2011).

    4. Lauritzen, G., Stock, C.M., Lemarie, J., et al. The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Lett. 317(2), 172-183 (2012).

    5. Orlowski, A., Vargas, L.A., Aiello, E.A., et al. Elevated carbon dioxide upregulates NBCn1 Na+/HCO3- cotransporter in human embryonic kidney cells. Am. J. Physiol. Renal Physiol. 305(12), F1765-F1774 (2013).

    6. Giambelluca, M.S., Ciancio, M.C., Orlowski, A., et al. Characterization of the Na/HCO3- cotransport in human neutrophils. Cell. Physiol. Biochem. 33(4), 982-990 (2014).