A non-specific Kv channel blocker
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4-Aminopyridine

Item No. 18511

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-pyridinamine
CAS Number
504-24-5
Synonyms
  • 4-AP
  • BRL 34915
  • Dalfampridine
  • Fampridine
  • NSC 15041
Molecular Formula
C5H6N2
Formula Weight
94.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mLPBS (pH 7.2): 2 mg/mL
λmax
245 nm
SMILES
NC1=CC=NC=C1
InChi Code
InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChi Key
NUKYPUAOHBNCPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $36

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    25 g

    $48

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    50 g

    $77

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    100 g

    $135

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    Product Description

    4-Aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+-channels (Kv proteins in the KCN gene family). It has greatest potency at Kv1 (KCNA) and Kv3 (KCNC) family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively).1 4-AP also blocks Kv2 and Kv4 subunits at millimolar concentrations.1 When administered orally, 4-AP has benefits against multiple sclerosis, while injection into the brain produces epileptiform activity and can be used to study seizures.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gutman, G.A., Chandy, K.G., Grissmer, S., et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57(4), 473-508 (2005).

    2. Blight, A.R., Henney, H.R., III, and Cohen, R. Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis. Ann. N. Y. Acad. Sci. 1329, 33-44 (2014).

    3. Jensen, H.B., Ravnborg, M., Dalgas, U., et al. 4-Aminopyridine for symptomatic treatment of multiple sclerosis: A systematic review. Ther. Adv. Neurol. Disord. 7(2), 97-113 (2014).

    4. Medina-Ceja, L., Flores-Ponce, X., Santerre, A., et al. Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus. J. Biomed. Sci. 22, (2015).