A selective LYPLA1 inhibitor
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ML-348

Item No. 18523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
CAS Number
899713-86-1
Synonyms
  • CID-3238952
  • SID 160654487
Molecular Formula
C18H17ClF3N3O3
Formula Weight
415.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
248 nm
SMILES
O=C(NC1=C(Cl)C=CC(C(F)(F)F)=C1)CN2CCN(C(C3=CC=CO3)=O)CC2
InChi Code
InChI=1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)
InChi Key
OXKNHBBDOIMFFQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.1,2 Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.1,2 ML-348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM.3 It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martin, B.R., and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nat. Methods 6(2), 135-138 (2009).

    2. Dekker, F.J., Rocks, O., Vartak, N., et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat. Chem. Biol. 6(6), 449-456 (2010).

    3. Adibekian, A., Martin, B.R., Chang, J.W., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1). (2010).

    Product Citations

    Patel, R., Santoro, A., Hofer, P., et al. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature (2021).