A selective S1P4 agonist
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ML-178

Item No. 18527

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-pyridine
CAS Number
1355026-47-9
Synonyms
  • CID-44620892
  • CYM 50179
  • SID 87544119
Molecular Formula
C13H9Br2Cl2NO2
Formula Weight
441.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS(pH7.2) (1:2): 0.3 mg/mLDMSO: 15 mg/mL
λmax
231, 291 nm
SMILES
ClC1=CC(Cl)=C(OCCOC2=C(Br)N=C(Br)C=C2)C=C1
InChi Code
InChI=1S/C13H9Br2Cl2NO2/c14-12-4-3-11(13(15)18-12)20-6-5-19-10-2-1-8(16)7-9(10)17/h1-4,7H,5-6H2
InChi Key
KMGUBUXDNOMSRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    ML-178 activates S1P4 with an EC50 value of 46.3 nM and is inactive against S1P1, S1P2, S1P3, and S1P5 (EC50s = >50 µM) and has no effect against a panel of additional receptors, transporters, and ion channels.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guerrero, M., Urbano, M., Velaparthi, S., et al. Probe development efforts to identify novel agonists of the sphingosine 1-phosphate receptor 4 (S1P4). (2010).