A selective 12-LO inhibitor
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ML-355

Item No. 18537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide
CAS Number
1532593-30-8
Molecular Formula
C21H19N3O4S2
Formula Weight
441.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
300 nm
SMILES
COC1=C(O)C(CNC2=CC=C(S(NC3=NC4=C(C=CC=C4)S3)(=O)=O)C=C2)=CC=C1
InChi Code
InChI=1S/C21H19N3O4S2/c1-28-18-7-4-5-14(20(18)25)13-22-15-9-11-16(12-10-15)30(26,27)24-21-23-17-6-2-3-8-19(17)29-21/h2-12,22,25H,13H2,1H3,(H,23,24)
InChi Key
OWHBVKBNNRYMIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $367

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    25 mg

    $783

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    Product Description

    ML-355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 µM.1 It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM) and no inhibition of COX-1 and -2.1 In cell-based assays, ML-355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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