ML-355

ML-355 is a selective inhibitor of 12-LO with an IC₅₀ value of 0.34 µM.¹ It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC₅₀s = 9.7, >100, and >100 µM) and no inhibition of COX-1 and -2.¹ In cell-based assays, ML-355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.¹

WARNING This product is not for human or veterinary use.

1. Luci, D.K., Jameson, J.B., II, Yasgar, A., et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J. Med. Chem. 57(2), 495-506 (2014).

Fuchs, D., Tang, X., Johnsson, A.-K., et al. Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent process. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865(4), 158611 (2020).

Chu, B., Kon, N., Chen, D., et al. ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat. Cell Biol. 21(5), 579-591 (2019).