A suppressor of mitochondrial electron leak
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S3QEL-2

Item No. 18556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
890888-12-7
Molecular Formula
C19H25N5
Formula Weight
323.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: slightly soluble
λmax
243, 298 nm
SMILES
CCCN(CCC)C1=C(C=NN2C3=CC(C)=C(C)C=C3)C2=NC=N1
InChi Code
InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3
InChi Key
MGIAJZSCNPODRR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $178

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    Product Description

    S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function.1 It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Orr, A.L., Vargas, L., Turk, C.N., et al. Suppressors of superoxide production from mitochondrial complex III. Nat. Chem. Biol. 11, 834-840 (2015).