Adduct of 15-d-PGJ2 and glutathione
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15-deoxy-Δ12,14-Prostaglandin J2 Glutathione

Item No. 18580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-S-[(2R,3E)-2-[(2Z)-6-carboxy-2-hexenyl]-3-(2E)-2-octenylidene-4-oxocyclopentyl]-L-cysteinyl-glycine
Synonyms
  • 15-deoxy-Δ12,14-PGJ2 Glutathione
Molecular Formula
C30H45N3O9S
Formula Weight
623.8
Purity
≥90%
Formulation (Request formulation change)
A 100 µg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
299 nm
SMILES
O=C(N([H])CC(O)=O)[C@H](CSC1CC(/C([C@H]1C/C=C\CCCC(O)=O)=C/C=C/CCCCC)=O)N([H])C(CC[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C30H45N3O9S/c1-2-3-4-5-6-9-12-20-21(13-10-7-8-11-14-27(36)37)25(17-24(20)34)43-19-23(29(40)32-18-28(38)39)33-26(35)16-15-22(31)30(41)42/h6-7,9-10,12,21-23,25H,2-5,8,11,13-19,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b9-6+,10-7-,20-12+/t21-,22+,23+,25?/m1/s1
InChi Key
PJVSKAKTGJJITI-YPYHUWNQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    50 µg

    $130

    Add

    100 µg

    $246

    Add

    500 µg

    $1,026

    Add
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    Product Description

    15-deoxy-Δ12,14-Prostaglandin J2 glutathione (15-deoxy-Δ12,14-PGJ2 glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.1,2,3 The biological properties of this compound have not been characterized.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cox, B., Murphey, L.J., Zackert, W.E., et al. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J2, to glutathione. Biochim. Biophys. Acta 1584(1), 37-45 (2002).

    2. Brunoldi, E.M., Zanoni, G., Vidari, G., et al. Cyclopentenone prostaglandin, 15-deoxy-Δ12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. Chem. Res. Toxicol. 20(10), 1528-1535 (2007).

    3. Paumi, C.M., Smitherman, P.K., Townsend, A.J., et al. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor γ (PPARγ) ligand, 15-deoxy-Δ12,14 prostaglandin J2 (15-d-PGJ2). Biochemistry 43(8), 2345-2352 (2004).