A monoamine and TAAR1 agonist
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Tyramine

Item No. 18601

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-aminoethyl)-phenol
CAS Number
51-67-2
Synonyms
  • 2-(4-Hydroxyphenyl)ethylamine
  • NSC 249188
  • p-Tyramine
  • Uteramine
Molecular Formula
C8H11NO
Formula Weight
137.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
224, 278 nm
SMILES
OC1=CC=C(CCN)C=C1
InChi Code
InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
InChi Key
DZGWFCGJZKJUFP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    25 g

    $128

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    50 g

    $236

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    100 g

    $428

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    Product Description

    Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.1,2,3 It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).1 Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reese, E.A., Bunzow, J.R., Arttamangkul, S., et al. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J. Pharmacol. Exp. Ther. 321(1), 178-186 (2007).

    2. Zucchi, R., Chiellini, G., Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149(8), 967-978 (2006).

    3. Maguire, J.J., Parker, W.A.E., Foord, S.M., et al. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev. 61(1), (2009).

    4. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).