A hydrophobic peptide chemosensitizer
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Reversin 121

Item No. 18603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1,1-dimethylethyl) 1-(phenylmethyl) ester N-[(1,1-dimethylethoxy)carbonyl]-L-a-aspartyl-N6-[(phenylmethoxy)carbonyl]-L-lysine
CAS Number
174630-04-7
Molecular Formula
C34H47N3O9
Formula Weight
641.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 12 mg/ml
SMILES
O=C(OCC1=CC=CC=C1)NCCCC[C@H](NC([C@H](CC(OCC2=CC=CC=C2)=O)NC(OC(C)(C)C)=O)=O)C(OC(C)(C)C)=O
InChi Code
InChI=1S/C34H47N3O9/c1-33(2,3)45-30(40)26(19-13-14-20-35-31(41)44-23-25-17-11-8-12-18-25)36-29(39)27(37-32(42)46-34(4,5)6)21-28(38)43-22-24-15-9-7-10-16-24/h7-12,15-18,26-27H,13-14,19-23H2,1-6H3,(H,35,41)(H,36,39)(H,37,42)/t26-,27-/m0/s1
InChi Key
SVNKEDMVAQBLLN-SVBPBHIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Cayman Chemical
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    Product Description

    Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM.1,2 Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharom, F.J., Yu, X., Lu, P., et al. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells. Biochem. Pharmacol. 58(4), 571-586 (1999).

    2. Kwak, E.L., Sordella, R., Bell, D.W., et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc. Natl. Acad. Sci. USA 102(21), 7665-7670 (2005).

    Product Citations

    Rana, P.S., Gibbons, B.A., Vereninov, A.A., et al. Calibration and characterization of intracellular Asante Potassium Green probes, APG-2 and APG-4. Anal. Biochem. 567, 8-13 (2019).