An AChE reactivator
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Isomer(s)
36587Obidoxime (chloride)
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Small Molecule Modulators
Small Molecule Activators

Research Area

Neuroscience

Asoxime (chloride)

Item No. 18607

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium, dichloride
CAS Number
34433-31-3
Synonyms
  • HI-6
Molecular Formula
C14H16N4O3 • 2Cl
Formula Weight
359.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/mL
λmax
217, 300 nm
SMILES
O/N=C\C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]
InChi Code
InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
InChi Key
QELSIJXWEROXOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Asoxime is an asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates.1 It demonstrates therapeutic activity in experimental models of organophosphate poisoning, by reactivating phosphorylated AChE that was inhibited as a result of exposure to various cytotoxic nerve agents.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, L., Radic, Z., Brüggermann, R.J.M., et al. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Biochemistry 39(19), 5750-5757 (2000).

    2. RamaRao, G., Afley, P., Acharya, J., et al. Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. BMC Neurosci. 15, (2014).

    3. Cochran, R., Kalisiak, J., Küçükkilinç, T., et al. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. The Journal of Biological Chemisty 286(34), 29718-29724 (2011).