An intermediate in the synthesis of ipratropium
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N-Isopropylnoratropine

Item No. 18611

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester α-(hydroxymethyl)-benzeneacetic acid
CAS Number
22235-81-0
Synonyms
  • NINA
Molecular Formula
C19H27NO3
Formula Weight
317.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 10 mg/mLEthanol: 16 mg/mLPBS (pH 7.2): 10 mg/mL
SMILES
O=C(C(CO)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H](N3C(C)C)C2
InChi Code
InChI=1S/C19H27NO3/c1-13(2)20-15-8-9-16(20)11-17(10-15)23-19(22)18(12-21)14-6-4-3-5-7-14/h3-7,13,15-18,21H,8-12H2,1-2H3/t15-,16+,17+,18?
InChi Key
VORSMCHHJRVORT-KCUXLOIUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    N-Isopropylnoraptropine is used in the synthesis of ipratropium, a bronchodilator compound with nonselective muscarinic antagonist activity.1 It has been used to examine the stability of ipratropium.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kasawar, G.B., and Farooqui, M. Development and validation of a stability indicating RP-HPLC method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. J. Pharm. Biomed. Anal. 52(1), 19-29 (2010).