A selective β3-adrenergic receptor partial agonist
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L-755,507

Item No. 18629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
CAS Number
159182-43-1
Molecular Formula
C30H40N4O6S
Formula Weight
584.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
228, 265 nm
SMILES
OC1=CC=C(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=C(NC(NCCCCCC)=O)C=C3)(=O)=O)C=C2)C=C1
InChi Code
InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
InChi Key
NYYJKMXNVNFOFQ-MHZLTWQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $203

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    50 mg

    $869

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    Product Description

    L-755,507 is a partial agonist of β3-adrenergic receptors (EC50 = 0.43 nM).1 It displays more than 440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively).1 At 5 µM, this compound has been used to enhance CRISPR-mediated homology-directed repair efficiency by 3-fold for large fragment insertions and by 9-fold for point mutations.2 L-755,507 has been used to identify signaling pathways activated through β3-adrenergic receptors.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parmee, E.R., Ok, H.O., Candelore, M.R., et al. Discovery of L-755,507: A subnanomolar humanβ3 adrenergic receptor agonist. Bioorg. Med. Chem. Lett. 8(9), 1107-1112 (1998).

    2. Yu, C., Liu, Y., Ma, T., et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16(2), 142-147 (2015).

    3. Sato, M., Hutchinson, D.S., Evans, B.A., et al. The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptor. Mol. Pharmacol. 74(5), 1417-1428 (2008).