An anti-protozoal diamidine
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Diminazene (aceturate)

Item No. 18678

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-glycine, compd. with 4,4′-(1-triazene-1,3-diyl)bis[benzenecarboximidamide] (2:1)
CAS Number
908-54-3
Molecular Formula
C14H15N7 • 2C4H7NO3
Formula Weight
515.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
231, 376 nm
SMILES
N=C(N)C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1.OC(CNC(C)=O)=O.OC(CNC(C)=O)=O
InChi Code
InChI=1S/C14H15N7.2C4H7NO3/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18;2*1-3(6)5-2-4(7)8/h1-8H,(H3,15,16)(H3,17,18)(H,19,20);2*2H2,1H3,(H,5,6)(H,7,8)
InChi Key
OKQSSSVVBOUMNZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma, Babesia, and Cytauxzoon.1,2 Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins.3 Diminazene inhibits diamine oxidase with a Ki value of 13 nM.3 In Trypanosoma, transport proteins are important in the effectiveness of diminazene.4 In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mosqueda, J., Olvera-Ramírez, A., Aguilar-Tipacamú, G., et al. Current advances in detection and treatment of babesiosis. Curr. Med. Chem. 19(10), 1504-1518 (2012).

    2. daSilva Oliveria, G.L., and de Freitas, R.M. Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. Pharmacol. Res. 102, 135-157 (2015).

    3. Huang, T.L., Mayence, A., and Vanden Eynde, J.J. Some non-conventional biomolecular targets for diamidines. A short survey. Bioorg. Med. Chem. 22(7), 1983-1992 (2014).

    4. Munday, J.C., Settimo, L., and de Koning, H.P. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Front. Pharmacol. 6, 32 (2015).

    5. Sheony, V., Gjymishka, A., Jarajapu, Y.P., et al. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am. J. Respir. Crit. Care Med. 187(6), 648-657 (2013).