A suppressor of HDAC inhibitors
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ITSA1

Item No. 18681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-benzotriazol-1-yl(2,4-dichlorophenyl)-methanone
CAS Number
200626-61-5
Molecular Formula
C13H7Cl2N3O
Formula Weight
292.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 2 mg/ml
λmax
229, 300 nm
SMILES
O=C(C1=C(Cl)C=C(Cl)C=C1)N2C3=CC=CC=C3N=N2
InChi Code
InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
InChi Key
UVNLAUGZMOPBPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    25 mg

    $102

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    50 mg

    $178

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    100 mg

    $283

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    Product Description

    ITSA1 is a cell-permeable benzotriazole amide that blocks TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 µM.1 At the same concentration, ITSA1 also prevents TSA-mediated cell cycle arrest and apoptosis.1 It similarly blocks the action of the HDAC inhibitor SAHA (Item No. 10009929), preventing SAHA-induced hyperacetylation of tubulin in A549 cells.1 ITSA1 reduces TSA-regulated transcription in mouse embryonic stem cells and in zebrafish.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koeller, K.M., Haggarty, S.J., Perkins, B.D., et al. Chemical genetic modifier screens: Small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem. Biol. 10(5), 397-410 (2003).