A seizure-inducing compound
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Pentylenetetrazole

Item No. 18682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7,8,9-tetrahydro-5H-etrazolo[1,5-a]azepine
CAS Number
54-95-5
Synonyms
  • α,β-Cyclopentamethylenetetrazole
  • 1,5-Pentamethylenetetrazole
  • PTZ
  • NSC 5729
  • NSC 66489
Molecular Formula
C6H10N4
Formula Weight
138.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
N12C(CCCCC2)=NN=N1
InChi Code
InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
InChi Key
CWRVKFFCRWGWCS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $49

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    Product Description

    Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals.1 Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.2,3 PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Löscher, W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 20(5), 359-368 (2011).

    2. Snider, N.T., Nast, J.A., Tesmer, L.A., et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. Mol. Pharmacol. 75(4), 965-972 (2009).

    3. Kaufmann, K., Romaine, I.M., Days, E., et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem. Neurosci. 4(9), 1278-1286 (2013).

    4. Chaix, Y., Ferraro, T.N., Lapouble, E., et al. Chemoconvulsant-induced seizure susceptibility: Toward a common genetic basis? Epilepsia 48 Suppl 5, 48-52 (2007).

    5. White, H.S. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 38 Suppl 1, S9-S17 (1997).