A proton pump inhibitor
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Tenatoprazole

Item No. 18717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-3H-imidazo[4,5-b]pyridine
CAS Number
113712-98-4
Synonyms
  • TU-199
Molecular Formula
C16H18N4O3S
Formula Weight
346.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: 10 mg/ml
λmax
306 nm
SMILES
COC1=CC=C2C(N1)=NC(S(CC3=C(C)C(OC)=C(C)C=N3)=O)=N2
InChi Code
InChI=1S/C16H18N4O3S/c1-9-7-17-12(10(2)14(9)23-4)8-24(21)16-18-11-5-6-13(22-3)19-15(11)20-16/h5-7H,8H2,1-4H3,(H,18,19,20)
InChi Key
ZBFDAUIVDSSISP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $50

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    25 mg

    $85

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    50 mg

    $129

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    Product Description

    Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM.1 It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.1,2,3 Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uchiyama, K., Wakatsuki, D., Kakinoki, B., et al. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find. Exp. Clin. Pharmacol. 21(2), 115-122 (1999).

    2. Galmiche, J.P., Bruley Des Varannes, S., Ducrotté, P., et al. Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers. Aliment Pharmacol. Ther. 19(6), 655-662 (2004).

    3. Hunt, R.H., Armstrong, D., James, C., et al. Effect on intragastric pH of a PPI with a prolonged plasma half-life: Comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers. Am. J. Gastroenterol. 100(9), 1949-1956 (2005).