An immunomodulatory dipeptide
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Pidotimod

Item No. 18725

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(2S)-5-oxo-2-pyrrolidinyl]carbonyl]-4R-thiazolidinecarboxylic acid
CAS Number
121808-62-6
Synonyms
  • PGT/1A
Molecular Formula
C9H12N2O4S
Formula Weight
244.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
O=C1CC[C@@H](C(N2[C@H](C(O)=O)CSC2)=O)N1
InChi Code
InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
InChi Key
UUTKICFRNVKFRG-WDSKDSINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    Cayman Chemical
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    Product Description

    Pidotimod is a synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies.1 It has been shown to induce dendritic cell (DC) maturation, to upregulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, to stimulate the release of pro-inflammatory molecules from DCs, which drives T cell proliferation and differentiation towards a Th1 phenotype, to enhance natural killer cell functions, to inhibit thymocyte apoptosis, and to promote phagocytosis.2 Through separate effects on ERK1/2 and NF-κB, pidotimod was shown to increase the expression of toll-like receptor 2 proteins. Pimotimod does not affect expression of ICAM-1 or the release of IL-8.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riboldi, P., Gerosa, M., and Meroni, P.L. Pidotimod: A reappraisal. Int.J.Immunopathol.Pharmacol. 22(2), 255-262 (2009).

    2. Zuccotti, G.V., and Mameli, C. Pidotimod: The past and the present. Ital.J.Pediatr. 39, (2013).