An electron acceptor
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Coenzyme Q1

Item No. 18741

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dimethoxy-5-methyl-6-(3-methyl-2-buten-1-yl)-2,5-cyclohexadiene-1,4-dione
CAS Number
727-81-1
Synonyms
  • CoQ1
  • NSC 268269
  • Ubiquinone-1
  • Ubiquinone-5
Molecular Formula
C14H18O4
Formula Weight
250.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlEthanol: 10 mg/ml
λmax
274 nm
SMILES
O=C1C(OC)=C(OC)C(C(C/C=C(C)/C)=C1C)=O
InChi Code
InChI=1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3
InChi Key
SOECUQMRSRVZQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $367

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    Product Description

    Coenzyme Q1 (CoQ1) is an electron acceptor and a derivative of the mitochondrial electron transport chain cofactor CoQ10 (Item No. 11506).1 It induces opening of the mitochondrial permeability transition pore and apoptosis in clone 9 cells when used at a concentration of 50 µM.2 Coenzyme Q1 has been used in the detection of mitochondrial complex I, also known as NADH dehydrogenase, activity in perfused tissue and subcellular fractions.3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fato, R., Estornell, E., DiBernardo, S., et al. Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles. Biochemistry 35(8), 2705-2716 (1996).

    2. Devun, F., Walter, L., Belliere, J., et al. Ubiquinone analogs: A mitochondrial permeability transition pore-dependent pathway to selective cell death. PLoS One 5(7), (2010).

    3. Bongard, R.D., Myers, C.R., Lindemer, B.J., et al. Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 302(9), L949-L958 (2012).