A natural PAF analog
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PAF C-18:1

Item No. 18779

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7R-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacos-18Z-en-1-aminium, 4-oxide inner salt
CAS Number
85966-90-1
Synonyms
  • 1-Oleyl-2-acetyl-sn-glycero-3-phosphorylcholine
  • Platelet-activating Factor C-18:1
Molecular Formula
C28H56NO7P
Formula Weight
549.7
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 20 mg/mlWater: 20 mg/ml
SMILES
CC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCC/C=C\CCCCCCCC)=O
InChi Code
InChI=1S/C28H56NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h13-14,28H,6-12,15-26H2,1-5H3/b14-13-/t28-/m1/s1
InChi Key
ZBOQHUSCQCEBGK-JLRCLJKCSA-N
Side Chain Carbon Sum
20:1
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $161

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    25 mg

    $381

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    Product Description

    PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 (Item No. 60900) and PAF C-18 (Item No. 60910) in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration.1,2 PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recognition at this receptor.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carolan, E.J., and Casale, T.B. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. J. Immunol. 145(8), 2561-2565 (1990).

    2. Erger, R.A., and Casale, T.B. Eosinophil migration in response to three molecular species of platelet activating factor. Inflamm. Res. 45(6), 265-267 (1996).

    3. Smal, M.A., Baldo, B.A., and Harle, D.G. The specificity of the binding of platelet activating factor (PAF) to anti-PAF antibodies. J. Mol. Recognit. 3(4), 169-173 (1990).